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doi: 10.1016/s0022-5347(17)35998-0

Discussion In the era of direct-acting antivirals against HCV infection, an accurate genotyping as well as a reliable discrimination between subtype 1a and 1b remains clinically and epidemiologically relevant 9,10,32

[PMC free article: PMC4648056] [PubMed: 26025389] 745

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An imbalance of the gut microbiota can lead to immune activation and inflammation, particularly through an increase in pro-inflammatory lipopolysaccharides (LPS), which results in increased production of inflammatory cytokines, such as TNF-, IL-1, and IL-6 (218)

Patients deficient in leptin fail to control feeding and as a result become severely obese, indicating that a single gene mutation is sufficient to affect feeding behavior 3,4