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Our previous finding that pharmacological inhibition of extracellular HMGB1 attenuated NIHL supports the relevance of this pathway, yet how GSDMD is activated by acoustic overstimulation and contributes to HC loss is unknown 13

These triggers stimulate insulin and epinephrine release, driving potassium intracellularly via the Na + /K + -ATPase and causing transient, profound hypokalemia

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Human cystatin C, a cysteine protease inhibitor that belongs to the cystatin superfamily, is a secretory type 2 cystatin, expressed in all nucleated human cells and found in all tissues and body fluids and at particularly high concentrations in cerebrospinal fluid 2,7,8,9

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