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The activation of the Nrf2 pathway triggers a massive endogenous production of Phase II detoxification enzymes, including Heme Oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1)

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In humans, heavy exposure to trichloroethylene is associated with an increased risk of cancer to the kidney (Brauch et al., 2004, Rusyn et al., 2014, Alanee et al., 2015) and possibly to the liver (Hansen et al., 2013, Vlaanderen et al., 2013), PD (Gash et al., 2008), and damage to the fifth cranial (trigeminal) nerve, sensory nucleus of the brainstem (Buxton and Haywood, 1967), and other nervous tissues (Chiu et al., 2013)

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This is consistent with the thesis stated before [40]