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The positive and negative opposing regulation of growth hormone by GHRH and somatostatin, respectively, creates a rhythmic-circadian pattern of GH secretion

Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls

It also reduces hepatic fat accumulation, which independently worsens insulin sensitivity a relevant secondary benefit given that non-alcoholic fatty liver disease is significantly more prevalent in women with PCOS

doi: 10.1016/j.ebiom.2016.01.024 69 MatzELTerleckiRP