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Nicotine pretreatment attenuated the loss of dopaminergic cells in MPTP-induced mesencephalic neurons (Quik and Jeyarasasingam, 2000)

Decreased GSH leads to a cascade of events, including an inability to mitigate oxidative stress, a subsequent increase in the release of cytokines IL-6 and TGF-, both of which are shown to further decrease GSH synthesis, and an increase in platelet activation, contributing to microclot formation

* For the GSH levels, two statistical outliers (one control and one participant with past MDD) were excluded

Its sulfhydryl (-SH) group gives it powerful biochemical properties

doi: 10.2174/1389203719666181026170049

Pathogens 9, 496