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E3 ligase ligand chemistries: from building blocks to protein degraders

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Its derived from a naturally occurring protein found in human stomach (gastric) juice, which is part of the reason researchers first became interested in it the body already produces a version of this compound as part of its natural protective processes

It belongs to a wider set of peptides moving through longevity and biohacker circles, including BPC-157, Cerebrolysin, Semax, Selank, Dihexa, P21, and the neurotrophic factors BDNF and klotho, whose human cognitive evidence ranges from thin to absent and which I reviewed in detail here

Subcellular -adrenergic receptor signaling in cardiac physiology and disease

The asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): opportunities and challenges