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As it is known that transactivation of Met can occur via epidermal growth factor (EGF)-dependent EGF receptor (EGFR) activation or through a constitutively activated EGFR pathway 20 , we examined whether inhibition of EGF-induced phosphorylation of EGFR by the dimeric macrocycles caused the bell-shaped response mentioned above

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Nat Biotech 29:625634 Wold S, Sjstrm M, Eriksson L (2001) PLS-regression: a basic tool of chemometrics

a three-arm, multicenter randomized clinical trial

Awarded the Nobel Prize alongside Jerne in 1984, Milstein and Khler's innovation could not have happened without the first step taken by Jerne in 1955

consequently, fiber photometry recordings were performed in mice aged P80-90 (Fig