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Mechanistically, the risk is attributed to the pharmacokinetic impact of piperine, which inhibits CYP3A4 and disrupts glucuronidation, increasing systemic curcumin exposure by over 20-fold and potentially converting otherwise safe doses into hepatotoxic levels in susceptible individuals

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On the other hand, the palatability of desserts and confectioneries, such as cakes, sweets, and ice cream, is mainly based on high amounts of sugars and fats with the supplementation of a low concentration of NaCl

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