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Pairwise comparisons showed that all species of ACs were increased in ALF groups compared with the control ( p 5-fold higher than the control group

doi: 10.1111/j.1432-1033.1978.tb12178.x

This may be due to the targeting effect of the failing myocardium-targeting peptide CTP in the nanoparticles, as achieving greater myocardial accumulation reduces the therapeutic dosage and attenuates pulmonary burden during nebulization

Another study found lipid deposition in the lacrimal glands of model animals prior to lymphocyte infiltration, with the accumulation primarily consisting of cholesterol esters (CEs)

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Moreover, one year after completion of the 12-week treatment, the active group had an average improvement of VAS scores (including less rescue medication) of 27%