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Exhaustion of spleen-derived immune cells and consequent reduction in splenic volume results in immunosuppression

Regarding metabolic inhibitors: HIF-1 inhibitors (e.g., PX-478) can specifically inhibit the enhancement of glycolysis and reduce the release of inflammatory factors (118, 119)

PMID: 36612194
Taken together, oral GSH supplementation in diabetic patients appears to have a stabilizing effect on HbA1c, i.e., it decreases rapidly within three months and continues thereafter

10.1038/ncomms1722 48 RahmanI.KodeA.BiswasS
