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Under iron-catalytic conditions, maintenance of the Fe 2 + /Fe 3 + redox couple promotes extensive peroxidation of PUFA-containing membrane phospholipids and drives ferroptotic execution in cancer cells 190,191

Current dose is 0.5 mg weekly after 4 weeks at 0.25 mg

Twenty-four hours after the administration of DMSO-loaded (1%) polymerosomes to the serum-free culture medium, a 21% decrease in sulfane sulfur-containing compounds level in the Naglu / cells, as well as a decrease in glutathione levels by 35% (in the WT line), and 14% (in the Naglu / line) compared to levels determined in their control groups, were observed (Table 1)

4 ArnoldL.HenryA.PoronF.Baba-AmerY.van RooijenN.PlonquetA.et al (2007)

PMID: 295 OlayioyeMA