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Other redox-based therapies such as AEOL10150, salicylamine, Coenzyme Q10, and NAC have also been shown to restore GSH homeostasis, which is critical to control inflammation, leading to reduction of seizure burden or comorbidities in animal models (Shin et al., 2005

Furthermore, compensatory changes in signalling molecules, such as the downregulation of carbonic anhydrase IV and the upregulation of CD38 and gamma-glutamyl transferase, further reflect the disruption of key metabolic and signalling pathways

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Increased LPL activity is mediated to a large extent by reduced hepatic production of apoC-III (an LPL inhibitor)

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