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2018) primarily due to two studies with very small s.d

Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFB activation

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

Secondary outcomes The secondary outcomes are as follows: type 2 diabetes, glucose, HbA1c, insulin, lipid profile (LDL-cholesterol, HDL-cholesterol, triglycerides and apolipoprotein B), systolic blood pressure, diastolic blood pressure, and body mass index (BMI), which are well-established risk factors for CVD in clinical practice, or recently identified to be related to CVD in MR, such as apolipoprotein B [30, 31]

doi: 10.1007/BF00967446

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