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Differential gene expression analysis revealed a continuous trajectory of transcriptional changes with stage of disease progression from MASLD to advanced MASH (Supplemental Figure 7, A and B), indicating substantial transcriptional remodeling during MASLD/MASH progression

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Notably, the catalytic subunit of glutamate-cysteine ligase (GCLC) was considerably reduced in KPC tumors under hyperglycemia ( Fig

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