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[DOI] [PMC free article] [PubMed] [Google Scholar] 113.Shimada K., Skouta R., Kaplan A., Yang W.S., Hayano M., Dixon S.J., Stockwell B.R

Acetaldehyde is the major metabolite mediated through CYP2E1

However, there is a controversy regarding the results of different studies

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The released TPA would then be incorporated into the host cells through the TPA transporter (PcaK) and further metabolized into protocatechuic acid (PCA) catalyzed by TPA 1,2-dioxygenase (TPADO) and 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase (DCDDH) (Figure 3)