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EPEA, N-eicosapentaenoyl ethanolamide

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doi:10.1016/j.taap.2012.09.021 Montet AM, Oliva L, Beauge F, Montet JC (2002) Bile salts modulate chronic ethanol-induced hepatotoxicity

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Environmental factors that are collectively referred to as the exposome can contribute to ROS buildup such as chemicals like nickel (Ni 2 ), cobalt (Co 2 ), and hard-metal particles (WCCo) used to simulate hypoxia in laboratory experiments and shown to stabilize HIF-1 through ROS generation [80, 81]