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We critically evaluate standardization gaps, validation requirements, and translational bottlenecks that determine whether multi-omics biomarkers can transition from research tools to clinical decision-support systems

Note: the heterocyclic rings of NAD and FAD are parallel and in contact through van der Waals interactions

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It has several isomers that have effects on metabolism

This notion is in keeping with the functional role of the glutamate-glutamine cycle and it fits with the model proposed by Hertz and Schousboe (59) based on analysis of kinetic data for glutamate uptake into cultured neurons and astrocytes

Undeniably, the brain is highly susceptible to ROS-induced oxidative damage, as a result of the existence of high amounts of polyunsaturated fatty acids and oxygen, due to the high oxygen consumption rate, thereby acting as a substrate for lipid peroxidation (Cobley et al