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12 Pathophysiology and signaling pathways involved T2D, usually accompanied by other manifestations of MDS, is a complex metabolic disease with multiple underlying mechanisms not fully understood, while IR and cell dysfunction are two core pathophysiological mechanisms 13,14 (Fig

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Although the number of patients was small, comprising nine patients with osteomyelofibrosis (OMF) and 11 patients with chronic myelocytic leukemia (CML), they revealed increased GST-Pi and MT expression in the bone marrow of MPD patients