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Deamidation of asparagine residues (present in TB-500s Asn in full-length T4, but the fragment contains no asparagine at positions 17-23) accelerates at alkaline pH but is minimized at pH 4-6

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Key considerations for B12 supplementation include the patients current B12 levels, anemia severity, and health status

The cost of a single vitamin B12 injection dose is 50 (per IM injection)