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The WHO initiated a working group to address G6PD deficiency as a significant global health issue with publication of a comprehensive classification of the disease, diagnosis, treatment, and prevention ( Populations with medium to high prevalence rates may have a national newborn screening program for early detection of this condition and guidelines in close monitoring of affected infants

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Clinical studies note reduced activity of key antioxidant enzymes, such as glutathione (GSH) peroxidase (GPX) in SAE patients, highlighting the potential vulnerability of antioxidant systems in disease progression ( The antioxidant defense system, especially GSH metabolism, is linked to neurodegenerative diseases (Wu et al., 2004), but its role in SAE in incompletely defined

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