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doi: 10.1002/mco2.298 60 LucaM.LucaA.CalandraC

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In addition to its role in the synthesis of cysteine, methionine is critical in the synthesis of the methyl donor, S-adenosylmethionine (SAM, SAMe, or AdoMet)

However, if the underlying cause of your deficiency remains such as pernicious anemia or ongoing medication use that impairs absorption your B12 levels will gradually decline after discontinuation