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Notably, accurate metal-affinity measurements can be challenging (Section 6.1), due to the tight affinities exhibited by many metal-protein complexes (such as 10 19 M for Cu(I)-CueR) [93]

Custdio, T

The notion of filament formation increasing stability is further supported by the His-tagged construct that presents longer polymers, higher stability, and less degradation than the construct without a His-tag (Fig

10.1002/mrd.1080350313

EAAC1 gene expression is promoted by nuclear factor erythroid 2-related factor 2 (Nrf2) [64], regulatory factor X1 (RFX1) [65], and all-trans-retinoic acid (ATRA) [66], while miR-96-5p, which is one of the microRNAs (miRNAs), has a target sequence in the 3-UTR of EAAC1 and suppresses the protein expression of EAAC1 posttranslationally, leading to decreased GSH levels in the brain [67,68] (Figure 3)

[DOI] [Google Scholar] 77.Sikiric P., Seiwerth S., Rucman R., Turkovic B., Rokotov D.S., Brcic L., Sever M., Klicek R., Radic B., Drmic D., et al