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in group 1, there was subtle decrease in density of

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Elevated mannose levels are also linked to a higher BMI, as obesity is associated with increased mannose concentrations

02 Reduced food cravings The combined effects on the brain's reward centers may help patients better control their food intake and reduce cravings for high-calorie foods

Br J Pharmacol 162:701711

3 Results 3.1 In vitro experiment 3.1.1 Cytotoxic effect of sitagliptin on HepG2 cells Sitagliptin exhibited a cytotoxic effect on HepG2 cells in a dose dependent manner, with IC50: 89 m, while at 3.9 m sitagliptin did not exert any cytotoxic effect (Table 1)