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Key transcription factors regulating the expression and induction of GCLC by pro- and anti-oxidants include nuclear respiratory factor NRF2/NRF1, activator protein-1 (AP-1), and nuclear factor kappa B (NFB)

together with regulation of selenoprotein expression, SELENOP-dependent Se uptake to the brain seems to play an important role in maintaining this strict hierarchy

S., Weon, K

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