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In rare instances, rapid bolus doses may lead to heart rate increases or other more serious reactions

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For example, studies demonstrated that A1298C genotype appeared to be the predominant linkage to the inattentive symptoms, leading to a 7.4-fold increase in ADHD, compared with a 1.3-fold increase for the C677T genotype 85 , individuals with ADHD seem to be related to A1298C polymorphisms 86

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doi: 10.3390/md14070121 68 IbrahimT