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FOR RESEARCH USE ONLY

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The downstream effects of NNMT inhibition by 5-amino-1MQ create a cascade of beneficial metabolic changes at the cellular level

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Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia

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K-means clustering analysis of amplicon sequence variants by animal demonstrated that NNMTi-treated DIO mice switched to LD had a distinct microbiome pattern that was highlighted by decreased Erysipelatoclostridium and increased Lactobacillus relative abundances compared to vehicle counterparts

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The temporal dynamics of 5-amino-1MQ's cellular effects reveal sophisticated regulatory mechanisms that extend well beyond immediate enzyme inhibition

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