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Besides, the curcumin nanoformulation prepared by chitosan-alginate complex had a 30% higher glucose-lowering effect in vivo than that prepared by chitosan only

2 Pathogenesis of Fibromyalgia The fact that pain is the hallmark of fibromyalgia has caused experts to believe that the disorder is neurogenic in origin, as it is associated with a central amplification of pain perception characterized most prominently by hyperalgesia (increased response to painful stimuli) and allodynia (pain from stimuli not normally painful)

A form of painful chronic thyroiditis with amyloid infiltration has also been described, and is probably etiologically distinct from Hashimoto's thyroiditis(100)

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