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Shinjyo N, Waddell G, Green J

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identified PERK as a specific receptor for TMAO, demonstrating that TMAO directly activates the PERK branch of the UPR at physiological concentrations, thereby inducing the transcription factor FoxO1, which is implicated in metabolic and inflammatory diseases (81)

Smith-Byrne K, et al

The patient panel strongly favored a medication-in-pocket approach for the treatment of acute gout flares
