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Ferroptosis may be regulated in IBD intestinal epithelial cells by phosphorylated AKT, ERK, IKK, and P65, providing new perspectives and strategies for the treatment of IBD, with MELK potentially being an effective target for IBD therapy

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Equivalent numbers of age-matched unsegregated flies were used for all experiments except survival assay

The authors concluded that melanocortin peptides provide a robust mechanism for targeting airway inflammation in lung disease