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Phenome-wide association studies (PheWas) of key druggable proteins Since most drugs are administered via the bloodstream, we applied PheWas to IGF2R and CST3 which had the strongest supporting evidence, to assess potential pleiotropic and toxic side effects

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A lack of riboflavin can show up as: angular cheilitis (cracks at the corners of the mouth) anemia burning mouth sore throat cataracts Riboflavin deficiency can also cause problems with iron absorption, leading to iron-deficiency anemia

A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes

Oxidative stress is thought to play a central role in the pathogenesis of these lung diseases

In addition, muscone modification enhanced the brain targeting ability of LF-modified liposomes and facilitated the brain delivery of DTX [142] ( Fig