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However, at higher extracellular concentrations compared to intracellular concentrations, thiamine enters the cell by passive diffusion, so that exogenous thiamin supplementation remains effective even when SLC19A3 is dysfunctional

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[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Chapman M.R., Robinson L.S., Pinkner J.S., Roth R., Heuser J., Hammar M., Normark S., Hultgren S.J