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doi: 10.1016/j.cell.2017.09.021 26 LeeSHwangNSeokBGLeeSLeeSJChungSW

Oxid Med Cell Longev 2022:3027514 Xin Y, Xu L, Zhang X, Yang C, Wang Q, Xiong X (2021) Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice

Notably, inactivation of Bach1 is a prerequisite for HO-1 induction, which is dominant over NRF2-mediated HO-1 transcription 53

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[ref] Too much ergothionine with gene + food in IBD: The variant of SLC22A4 linked to Crohns disease in the study referenced above, and also to mushroom intolerance for those with Crohns disease, causes a gain-of-function with a 50% increased transport of ergothioneine (ET)