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Dull Skin Or Dryness The skin often appears dull and has a coarse texture because the cells are not adequately supplied with water and nutrients

When that happens, your system can shift into overdrive, with inflammatory responders ever present

Nat Struct Mol Biol

The diagnostic process typically involves: Clinical history taking, focusing on symptoms (fatigue, neurological changes, dietary habits) Physical examination for signs of anaemia or neurological impairment Blood tests including full blood count, serum B12, and often folate levels Additional investigations such as intrinsic factor antibodies or parietal cell antibodies if pernicious anaemia is suspected For borderline results, additional tests like holotranscobalamin (active B12) may be considered NICE guidance recommends that treatment should commence based on clinical presentation if neurological symptoms are present, without waiting for laboratory confirmation, as delays can result in irreversible nerve damage

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These lifestyle factors can make it difficult to maintain balanced nutrition and consistent health habits