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Most participants approach weight loss plateau around weeks 40-48, though clinical trial data showed participants were still losing weight at study conclusion, suggesting even longer treatment courses might yield additional benefits

Then, gene-gene Pearson correlations were calculated using the cor function of the WGCNA package 111

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The ferroptosis signalling pathway is comprehensive, and in addition to the classical disorders of iron metabolism, the glutathionecysteamineglutathione system and polyunsaturated fatty acid metabolism, an increasing number of signalling pathways, such as nicotinamide adenine dinucleotide phosphate/ferroptosis-inhibitory protein 1 and tetrahydrobiopterin/GPT cycloheximide 1/dihydrofolate reductase, have been identified 51

Inhibitory effects of polyphenol punicalagin on type-II collagen degradation in vitro and inflammation in vivo