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Later, following the discovery of other isozymes with broader substrate specificity and tissue-specific localization, the cytosolic GPx from erythrocytes utilizing hydroperoxide (inorganic/organic) and GSH as the substrates was termed GPx1

Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96

The National Institutes of Health confirms that B12 deficiency directly impairs myelin production-the protective coating around nerve fibers that speeds up brain communication

[PubMed] [Google Scholar] Shi ZZ, Habib GM, Rhead WJ, Gahl WA, He X, Sazer S, Lieberman MW

Importantly, people who already have liver disease are at a higher risk of liver damage from acetaminophen because they likely arent producing enough glutathione