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Brain Res 902(1):92

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

Enzymatic antioxidant defense cannot rely solely on SOD, because that would result in markedly increased tissue damage due to high accumulated levels of intracellular H 2 O 2 , the substrate for production of OH via the Fenton reaction

Dendrimer-mediated delivery of DNA and RNA vaccines

Amino acids V12 (putative oxyanion hole), F112 (active site architecture), N108 (flavonoid binding) and C13 (GSH stabilization) were fully randomized by site saturation mutagenesis (NNK codons), and the created Pt GSTF8 variants were tested for conversion of flavan-3,3,4-triol ( 4 ) to cyanidin ( 8 ), and for their GSH-transferase activity towards CDNB ( 5 ) as a control of catalytic competence

In a separate arm of investigation, another 12 patients with cirrhosis received GSH 200 mg/d im without producing any difference in biochemical parameters