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Gastroenterology 135 , 11761184 (2008)

Figure 3 Despite the clinical evidence for microbial infection in AD, other neurodegenerative diseases such as Parkinsons disease and ALS also are influenced by microbial infections and induction of inflammatory processes with microglial and astrocytic activation (Lotz et al., 2021), which would question the primacy of microbes in AD

Fetal reversion enables villus-derived cells to regenerate tissue without exogenous oncogenic mutations To determine whether the fetal reversion and subsequent conversion to CBCs observed in Alpi+ enterocytes in vitro could also occur under more physiological conditions, we performed primary collagen culture of villus tissues containing tdTomato-labeled Alpi+ cells, followed by in vitro organoid expansion and subsequent transplantation experiments using a DSS-induced colitis model 23,24

Cell 90 , 595606 (1997)

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