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Materials and methods Cell culturing RWPE-1 (ATCC CRL-11609) epithelial cells and DU-145 (ATCC HTB-81) human prostate carcinoma cells were purchased from American Type Culture Collection (Manassas, Virginia, USA)
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Epigenetic Modulations: Researching how the preservation of S-adenosylmethionine (SAM) levelsvia NNMT blockadeaffects global DNA/histone methylation profiles and gene silencing mechanisms
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NNMT inhibition increases intracellular NAD+ by blocking nicotinamide methylation, but the long-term metabolic consequences of sustained NNMT suppression
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