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Long-term chronic dosing beyond 30 days has not been characterised in peer-reviewed human studies, and caution is appropriate outside the registered indications

The depletion of GPX4 can increase the sensitivity of hepatocytes or cardiomyocytes to lipid peroxides, which can accelerate IRI-induced liver or cardiac injury [246248]

Messina A, Corvaia A, Marino C

Furthermore, to assess the potential of -hydroxybutyrate as a negative indicator for fasting, another study examined the changes in -hydroxybutyrate levels in patients without any form of organic hypoglycemia who underwent a 72-hour fast

Management of adult growth hormone deficiency

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