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Prevention of diabetes-induced cardiovascular complications upon treatment with antioxidants

This phase establishes whether the drug is safe enough to proceed to efficacy testing, operating under the core ethical principle of nonmaleficence to minimize potential harm to human subjects

The triad model was selected as the final model as the comproportionation reaction ( R 5 ) parameters ( k p5 and k m5 ) were the two least sensitive parameters with respect to model OCR output for both main and total effects during global sensitivity analysis (Fig

The nervous system also exerts significant control over hepatic lipid metabolism

99 Importantly, these natural compounds possess a remarkable antioxidant activity, and this effect is realized by activating the Keap1-Nrf2 pathway

Much of the hydrogen peroxide that is produced during oxidative cellular metabolism comes from the breakdown of one of the most damaging ROS, namely the superoxide anion radical (O 2 - )