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When NRF-2 is exposed to inflammation or oxidative stress (OS), it phosphorylates and translocates into the nucleus, giving rise to the transcription of proteins and antioxidant enzymes [7]

Both amino acids consist of the carboxylic acid chemical group

Microbial metabolites such as LPS, indoxyl sulfate (IS), and p-cresyl sulfate (pCS) have been shown to activate TGF-/Smad, NF-B, and mTOR pathwaysleading to mesothelial or epithelialmesenchymal transitions (MMT/EMT) and extracellular matrix deposition [128]

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Effects of short-term glucocorticoid deprivation on growth hormone (GH) response to GH-releasing peptide-6: studies in normal men and in patients with adrenal insufficiency