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To minimize any discomfort, practitioners often apply a topical numbing cream or use injectables that contain lidocaine, a mild anesthetic, to make the procedure more comfortable

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Shifts the balance of certain proteins inside cells toward survival signals and reduces activity of a protein involved in cell death, helping protect cells from dying off

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Sometimes the pain in the knee causes the brain to shut off the quadriceps muscle at the knee and leads to a "giving way" sensation

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