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Ethical Approval This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by the author

[8] Medications that target the genetic cause of the disease include nusinersen, risdiplam, [12] and the gene therapy medication onasemnogene abeparvovec

Furthermore, one of the most important brain metabolic markers is N-acetyl-aspartate (NAA) which contributes to the production of energy by the mitochondria

Aside from the traditional protein-based biomarkers, there is an increased interest on the development of analysis methods for newer metabolite-based biomarkers, including TMAO [3]