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Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through s-nitrosylation and inhibition of bcl-2 ubiquitination

NF-B inhibition delays DNA damage-induced senescence and aging in mice

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Combine this with inadequate nutrition, stress, lack of exercise, and hormonal changes that occur at midlife and beyond, and it's no wonder that moisturizers, creams, and anti-aging serums are a billion-dollar market

Unfortunately, none of these strategies have been successful