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Among 21,822 people of European ancestry, we required participants to have complete data needed to construct the target phenotype and GWAS covariates (that is, data available for pre-treatment weight, post-treatment weight, drug type, dosage, time on treatment and factors such as age, sex and height), resulting in 18,488 participants
Its primary therapeutic effects in diabetes management include glucose-dependent stimulation of insulin secretion, inhibition of glucagon release, delayed gastric emptying, and promotion of satiety
Acknowledgements This work was supported by grants from the Ministry of Research of France (fellowship to M
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In addition, rapid weight loss may also transiently alter chemistry in some people, potentially increasing the risk of stone formation during periods of active weight reduction