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Description
Disruption of mitochondrial complex I induces progressive parkinsonism
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How This Works PNC-27 is a chimeric 32-amino-acid peptide : a segment of the p53 tumor-suppressor protein (the HDM-2-binding domain, residues 1226) fused to a membrane-penetrating leader sequence [1] [2]
The KD group demonstrated improvements in lexical access (F(1,11) = 6.55, p = 0.02, Cohens f = 0.76) and memory (F(1,11) = 8.42, p = 0.01, f = 0.87), as well as a reduction in memory interference (F(1,11) = 4.03, p = 0.06, f = 0.60)
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