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This strategy has been exploited in the long-acting GLP-1RA semaglutide (Novo Nordisk), for instance, which was approved for treatment of T2DM in 2017, and for treatment of obesity in 2021, and has since then become the most prescribed GLP-1RA 92

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9 The Therapeutic Landscape of FcRn Antagonists Increasing IgG catabolism by specific FcRn targeting has proven to be a safe and efficacious strategy to lower the levels of autoreactive IgG in several autoimmune diseases

The compounding rules have hard dates

Nonn L, Duong D, Peehl DM
