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But compelling preclinical data does not translate reliably to human outcomes

Instead, the reader of an RCT publication should consider whether any differences observed between groups are clinically relevant and of a magnitude that may impact the outcomes being assessed in the trial

See our comparison of injectable vs oral peptides for more context

Derwa Y, Gracie DJ, Hamlin PJ, Ford AC

Importantly, most gastrointestinal events were mild-to-moderate in severity, and 92.8% of participants completed the full two-year trial, indicating that long-term tolerability was generally good

Multi-Pathway Cellular-Signaling Frameworks Bershadsky A