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doi: 10.1016/j.biopha.2021.111960

In general, three different groups of agents were described in the past: (i) mAbs, either targeting the ligand HGF or the receptor Met, (ii) tyrosine kinase inhibitors, targeting the tyrosine kinase domain of Met (and mostly also the TK domain of other RTKs), (iii) a truncated, soluble Met receptor serving as decoy for HGF (44) and the competitive HGF antagonist NK4 (18)

In FRDA, the persistent iron starvation signal and the lack of functional ferritin storage keep ferritinophagy upregulated [84]

Chemosphere 58:11531159 Paetzold SC, Ross NW, Richards RC, Jones M, Hellou J, Bard SM (2009) Up-regulation of hepatic ABCC2, ABCG2, CYP1A1, and GST in multixenobiotic-resistant killifish ( Fundulus heteroclitus ) from the Sydney Tar Ponds, Nova Scotia, Canada

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