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Proposed clinical trial studying exogenous ketone supplementation in ICU delirium To evaluate our hypotheses, we propose a prospective, randomized, placebo-controlled pilot study of exogenous ketone ester administration in critically ill patients to assess the safety and efficacy of this novel intervention in reducing the incidence or duration of ICU delirium

Some clinicians have reported successful use of small-volume subcutaneous injections, yet the formulation is approved and most widely studied for deep intramuscular delivery, so any off-label route should be discussed carefully with the prescriber

10.1016/j.canlet.2016.08.022 92 HuY

Since the FDA cannot assure the products quality and safety, as it has not undergone its evaluation process

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